Continuing EducationRh Negative Status and Isoimmunization Update A Case-Based Approach to CareHarrod, Kathryn Shisler DNSc, RN, CNM; Hanson, Lisa DNSc, RN, CNM; VandeVusse, Leona PhD, RN, CNM, FACNM; Heywood, Patricia MDAuthor Information From the Nurse-Midwifery Program, Marquette University College of Nursing, Milwaukee, Wis. (Harrod, Hanson, VandeVusse) The Division of Maternal–Fetal Medicine, Obstetrics and Gynecology Department, University of Wisconsin Medical School, Milwaukee Clinical Campus, Milwaukee, Wis. (Heywood) This article was supported in part by grant number 5D09HP00141 from the US Department of Health and Human Services. The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of the US Department of Health and Human Services. Corresponding author: Lisa Hanson, DNSc, RN, CNM, Nurse-Midwifery Program, Marquette University College of Nursing, PO Box 1881, Clark Hall, Milwaukee, WI 53201-1881 (e-mail: [email protected]). Submitted for publication: April 10, 2003 Accepted for publication: May 5, 2003 The Journal of Perinatal & Neonatal Nursing: July 2003 - Volume 17 - Issue 3 - p 166-180 Buy CE Test Abstract Prior to the 1970s and the advent of Rho (D) immune globulin (RIG) for Rh negative women, hemolytic disease of the newborn led to morbidity, long-term disabilities, and mortality. Antepartum RIG administration has been a standard of practice since 1983. Yet, Rh isoimmunization (sensitization) and its sequelae have not been completely eradicated. Rh-related issues remain clinical challenges facing perinatal and neonatal nurses. Evidence for the administration of RIG prenatally and during the postpartum period is presented including controversies and challenges. Current information about fetal and neonatal care of erythroblastosis fetalis and immune hydrops is also presented. © 2003 Lippincott Williams & Wilkins, Inc.