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Treatment and Outcome of Nonmetastatic Extraocular Retinoblastoma With a Uniform Chemotherapy Protocol

Bakhshi, Sameer MD* † ‡; Meel, Rachna MD§ ∥ ‡; Mohanti, Bidhu Kalyan MD¶ † ‡; Hasan Naqvi, Syed Ghaffar MD* † ‡

Journal of Pediatric Hematology/Oncology: March 2010 - Volume 32 - Issue 2 - p e42-e45
doi: 10.1097/MPH.0b013e3181bfcd83
Online Articles: Original Articles

Nonmetastatic extraocular retinoblastoma is a common entity in South-East Asia. We did a retrospective study of patients treated for isolated extraocular retinoblastoma, that is, International retinoblastoma staging system stages II and III, using a uniform chemotherapy protocol at our oncology center, between June 2003 and June 2008. Out of the 25 patients having nonmetastatic extraocular retinoblastoma, 6 were in stage II, and 19 in stage III. The probability of event-free survival was 0.54 at 18 months of follow-up with no significant difference between the 2 stages and the presence of optic nerve involvement; 11 out of 13 relapses were systemic. This is the largest case series of nonmetastatic extraocular retinoblastoma from South-East Asia.

*Department of Medical Oncology

§Oculoplastics and Ocular Oncology Service

Department of Radiotherapy

B.R.A. Institute Rotary Cancer Hospital

Rajendra Prasad Centre for Ophthalmic Sciences

All India Institute of Medical Sciences, New Delhi, India

Reprints: Sameer Bakhshi, MD, Associate Professor of Pediatric Oncology, Department of Medical Oncology, Dr B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India (e-mail:

Received for publication June 26, 2009

accepted September 2, 2009

Disclosure: None.

Supported by none.

© 2010 Lippincott Williams & Wilkins, Inc.