Online Articles: Clinical and Laboratory ObservationsRespiratory Failure in a Child With Pulmonary Metastatic Osteosarcoma and COVID-19Offenbacher, Rachel MD*,†; Fabish, Lara CPNP*,†; Baker, Alissa MD*,†; Chou, Alexander J. MD*,†; Loeb, David M. MD, PhD*,†Author Information *Department of Pediatrics, Albert Einstein College of Medicine †Division of Pediatric Hematology, Oncology and Marrow & Blood Cell Transplantation, Children’s Hospital at Montefiore, Bronx, NY The authors declare no conflict of interest. Reprints: David M. Loeb, MD, PhD, Department of Pediatrics, Children’s Hospital at Montefiore, 3411 Wayne Avenue, Room 910, Bronx, NY 10467 (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: August 2021 - Volume 43 - Issue 6 - p e859-e860 doi: 10.1097/MPH.0000000000001897 Buy Metrics Abstract The novel coronavirus, SARS-CoV-2, causes much more severe disease in adults than in children. Although it is anticipated that immune compromised children and children with cancer may be at higher risk of developing severe or fatal COVID-19, there are no currently published reports of fatal disease in a child with cancer. Because of the discrepancy in disease severity between adult and pediatric patients, we report the case of an adolescent with pulmonary metastatic osteosarcoma who died of COVID-19 early in the course of the pandemic in New York City in the hope that heightening awareness that pulmonary metastatic disease may predispose to a more severe outcome will increase surveillance in this vulnerable population. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.