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Successful Treatment of Relapsed Isolated Extraocular Retinoblastoma in the Right Fibula With High-dose Chemotherapy and Autologous Stem Cell Transplantation

Uppuluri, Ramya MBBS, MD, FNB; Jayaraman, Dhaarani MBBS, MD; Sivasankaran, Meena MBBS, DNB; Patel, Shivani MBBS, MD; Vellaichamy Swaminathan, Venkateswaran MBBS, MD; Raj, Revathi MBBS, DCH, MRCP, FRCPath

Journal of Pediatric Hematology/Oncology: July 2019 - Volume 41 - Issue 5 - p 402–403
doi: 10.1097/MPH.0000000000001462
Clinical and Laboratory Observations
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Literature on high-dose chemotherapy followed by autologous stem cell rescue in relapsed retinoblastoma is limited to <150 cases reported so far. We present our experience and the challenges faced in the management of a 7-year-old boy with relapsed isolated extraocular retinoblastoma in the right fibula who received salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell rescue. Electrolyte disturbances, renal tubulopathy, and seizures were the most significant transplant-related morbidity. The child is now 3 years postautograft in remission. Monitoring for second malignant neoplasm and late side effects remain the main challenges in the years to come.

Department of Paediatric Haematology, Oncology, Blood and Marrow Transplantation, Apollo Cancer Institutes, Chennai, Tamil Nadu, India

The authors declare no conflict of interest.

Reprints: Ramya Uppuluri, MBBS, MD, FNB, Department of Paediatric Haematology, Oncology, Blood and Marrow Transplantation, Apollo Cancer Institutes, 320, Padma Complex, Anna Salai, Teynampet, Chennai 600035, Tamil Nadu, India (e-mail: ramya.december@gmail.com).

Received January 21, 2018

Accepted February 14, 2019

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