Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems. Patients can have hematologic manifestations, including Evans syndrome (ES), which is characterized by immune-mediated thrombocytopenia and anemia. The association of neurofibromatosis 1 (NF1) with autoimmune disorders is rarely reported. We will review the literature for this combination of disorders and describe a case of a 16-year-old girl who presents with immune-mediated cytopenias and is diagnosed with SLE, ES, and NF1. There are 7 reported cases of SLE and NF1 and only 2 are pediatric cases. There are no reports of the combination of SLE, ES, and NF1.
*Department of Pediatrics
†Division of Adult & Pediatric Rheumatology
‡Division of Pediatric Hematology-Oncology, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children’s Hospital, St Louis, MO
Present address: Amy Moskop, MD, Department of Pediatrics, Medical College of Wisconsin, Children’s Hospital of Wisconsin, 8915 W Connell Ct, Milwaukee, WI 53226.
The authors declare no conflict of interest.
Reprints: Amy Moskop, MD, Department of Pediatrics, Medical College of Wisconsin, Children’s Hospital of Wisconsin, 8915 W Connell Ct, Milwaukee, WI 53226 (e-mail: email@example.com).
Received October 16, 2018
Accepted March 21, 2019