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Successful Treatment of an EBV-positive Diffuse Large B-Cell Lymphoma in a Patient With Trisomy 21

Putti, Maria C. MD*; Marzollo, Antonio MD, PhD*; Carraro, Elisa BS*; Boaro, Maria P. MD; Massano, Davide MD*; Mussolin, Lara PhD*,‡; Lovisa, Federica PhD*,‡; Tumino, Manuela MD, PhD*; Calore, Elisabetta MD, PhD*; Mainardi, Chiara MD, PhD*; Varotto, Elena MD*; d’Amore, Emanuele S.G. MD§; Pillon, Marta MD*

Journal of Pediatric Hematology/Oncology: April 30, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001502
Clinical and Laboratory Observations: PDF Only

Diffuse large B-cell Lymphoma (DLBCL) secondary to a chronic severe Epstein-Barr virus (EBV) infection has not been previously described in a patient with trisomy 21. Here we report the case of a 14-year-old girl with trisomy 21 with impaired control of EBV and DLBCL. She was cured with dose-adapted chemotherapy and hematopoietic stem cell transplantation without severe treatment-related toxicity. We describe the first case of EBV-positive DLBCL in a patient with trisomy 21 and we propose a treatment modality for this rare entity.

*Department of Women’s and Children’s Health, Pediatric Hematology-Oncology Unit, University of Padova

Institute of Pediatric Research, Città della Speranza Foundation, Padova

§Institute of Pathology, San Bortolo Hospital, Vicenza

Department of Pediatrics, St. Bassiano Hospital, Bassano del Grappa, Italy

M.C.P., A.M., E.C., M.P.B., D.M., M.T., E.C., C.M., E.V., M.P.: were involved in the clinical management of the patient. E.d’A.: performed the histologic examination. L.M. and F.L.: performed the clonality testing on the tumor specimen. A.M.: wrote the paper. L.M., C.M., E.V., and M.P.: critically reviewed the paper.

Supported by a grant from Fondazione Città della Speranza ONLUS (thanks to the initiative “Gusto per la Ricerca”) to A.M.

The authors declare no conflicts of interest.

Reprints: Antonio Marzollo, MD, PhD, Department of Women’s and Children’s Health, Pediatric Hematology-Oncology Unit, University of Padova, Via Giustiniani 3, Padova 35128, Italy (e-mail:

Received January 8, 2019

Accepted March 25, 2019

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