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Successful Management of Hepatosplenic Infection Due to Saccharomyces cerevisiae in a Child With Acute Lymphoblastic Leukemia

Davies, Emma MSc*; Shipp, Adam MBChB; Hawkes, Rob MD, FRCR; Wynn, Robert F. MD, FRCPath

Journal of Pediatric Hematology/Oncology: January 08, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001403
Clinical and Laboratory Observations: PDF Only

Saccharomyces cerevisiae is an emerging pathogen within the immunocompromised. We present a 4-year-old boy with acute lymphoblastic leukemia presenting with polymerase chain reaction-confirmed hepatosplenic S. cerevisiae infection and significant immune reconstitution symptoms. We explore the challenges of monitoring treatment efficacy using C-Reactive protein, β-D-glucan, and imaging and the administration of chemotherapy alongside antifungals and steroids for control of immune reconstitution syndrome.

*Department of Clinical Virology, Manchester University Foundation Trust

Departments of Paediatric Blood and Marrow

Paediatric Radiology, Royal Manchester Children’s Hospital, Manchester, United Kingdom

The authors declare no conflict of interest.

Reprints: Emma Davies, MSc, Department of Clinical Virology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom (e-mail:

Received June 22, 2018

Accepted December 3, 2018

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.