Saccharomyces cerevisiae is an emerging pathogen within the immunocompromised. We present a 4-year-old boy with acute lymphoblastic leukemia presenting with polymerase chain reaction-confirmed hepatosplenic S. cerevisiae infection and significant immune reconstitution symptoms. We explore the challenges of monitoring treatment efficacy using C-Reactive protein, β-D-glucan, and imaging and the administration of chemotherapy alongside antifungals and steroids for control of immune reconstitution syndrome.
*Department of Clinical Virology, Manchester University Foundation Trust
Departments of †Paediatric Blood and Marrow
‡Paediatric Radiology, Royal Manchester Children’s Hospital, Manchester, United Kingdom
The authors declare no conflict of interest.
Reprints: Emma Davies, MSc, Department of Clinical Virology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, United Kingdom (e-mail: firstname.lastname@example.org).
Received June 22, 2018
Accepted December 3, 2018