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Severe Factor X Deficiency Presenting as Febrile Seizure in an Infant

Garg, Meenal MD*; Ramzan, Mohammed MD; Kumawat, Anand MD; Mittal, Jaikrishan MD, DM§; Katewa, Satyendra MD; Gupta, Piyush MS

Journal of Pediatric Hematology/Oncology: March 12, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001453
Clinical and Laboratory Observations: PDF Only

Factor X deficiency is a severe inherited coagulation disorder, which is characterized by severe systemic bleeding manifestations in affected individuals. It is a rare disorder with a frequency of around 1:1,000,000 in the general population. We present the case of an infant with factor X deficiency who presented with complex febrile seizure. Although febrile seizures are very common in children, a closer scrutiny leads to neuroimaging and finding of intracranial bleed. Hematological and genetic investigations confirmed the diagnosis. A high index of suspicion should be maintained to diagnose uncommon bleeding disorders in children.

*Department of Pediatric Neurology, Neoclinic Children Hospital

Department of Pediatric Hemato-oncology, Manipal Hospital

Department of Pediatrics, Sawai Man Singh Medical College and JK Lon Hospital

§Department of Pediatrics and Neonatology, Neoclinic Hospital

Department of Corneal Surgery and Ophthalmology, SK Soni Hospital, Jaipur, Rajasthan, India

Written informed consent was obtained from the patient’s guardians for publication of the case and any accompanying images. A copy is available for review by the editor of this journal.

M.G.: conceptualized the study, acquired clinical data, and prepared the manuscript. M.R.: critically revised the initial manuscript. A.K.: acquired clinical data and helped in manuscript revision. J.M., S.K., and P.G.: conducted the literature search and manuscript editing.

The authors declare no conflict of interest.

Reprints: Meenal Garg, MD, Neoclinic Children Hospital, Nirman Nagar, Jaipur 302019, Rajasthan, India (e-mail:

Received January 3, 2019

Accepted January 27, 2019

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