Factor X deficiency is a severe inherited coagulation disorder, which is characterized by severe systemic bleeding manifestations in affected individuals. It is a rare disorder with a frequency of around 1:1,000,000 in the general population. We present the case of an infant with factor X deficiency who presented with complex febrile seizure. Although febrile seizures are very common in children, a closer scrutiny leads to neuroimaging and finding of intracranial bleed. Hematological and genetic investigations confirmed the diagnosis. A high index of suspicion should be maintained to diagnose uncommon bleeding disorders in children.
*Department of Pediatric Neurology, Neoclinic Children Hospital
†Department of Pediatric Hemato-oncology, Manipal Hospital
‡Department of Pediatrics, Sawai Man Singh Medical College and JK Lon Hospital
§Department of Pediatrics and Neonatology, Neoclinic Hospital
∥Department of Corneal Surgery and Ophthalmology, SK Soni Hospital, Jaipur, Rajasthan, India
Written informed consent was obtained from the patient’s guardians for publication of the case and any accompanying images. A copy is available for review by the editor of this journal.
M.G.: conceptualized the study, acquired clinical data, and prepared the manuscript. M.R.: critically revised the initial manuscript. A.K.: acquired clinical data and helped in manuscript revision. J.M., S.K., and P.G.: conducted the literature search and manuscript editing.
The authors declare no conflict of interest.
Reprints: Meenal Garg, MD, Neoclinic Children Hospital, Nirman Nagar, Jaipur 302019, Rajasthan, India (e-mail: firstname.lastname@example.org).
Received January 3, 2019
Accepted January 27, 2019