Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

QT Interval Prolongation in the Pediatric Oncologic Population on Methadone

Piccininni, Jenna A. MD*; Killinger, James S. MD†,‡,§; Hammad, Hoda T. MS, MPH; Gerber, Linda M. PhD, MA; Dayton, Jeffrey D. MD†,§,¶

Journal of Pediatric Hematology/Oncology: February 28, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001444
Clinical and Laboratory Observations: PDF Only
Buy
PAP

Studies have been conducted on adults prescribed with methadone to determine the necessary frequency of QTc monitoring but no consensus has been reached and no similar research has been conducted in the pediatric population. The objective of this retrospective study was to determine the occurrence rate of QTc interval prolongation associated with methadone use in a pediatric oncologic population. In total, 18% of patients developed QTc interval prolongation. These patients had longer baseline QTc intervals and were on more QTc interval-prolonging medications. Our data suggest that these variables may be able to risk stratify patients who require more frequent monitoring.

*Division of Pediatric Cardiology, NewYork Presbyterian/Columbia University Medical Center, Morgan Stanley Children’s Hospital of New York

Departments of Pediatrics

Healthcare Policy and Research, Division of Biostatistics and Epidemiology

Divisions of Pediatric Critical Care

Pediatric Cardiology, Weill Cornell Medicine

§Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY

This study was supported by the MSK Cancer Center Support Grant/Core Grant (P30 CA008748).

The authors declare no conflict of interest.

Reprints: Jenna A. Piccininni, MD, Division of Pediatric Cardiology, NewYork Presbyterian/Columbia University Medical Center, Morgan Stanley Children’s Hospital of New York, 3959 Broadway, New York, NY 10032 (e-mail: jep9124@nyp.org).

Received June 25, 2018

Accepted January 15, 2019

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.