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Osteosarcoma in a Child Below 2 Years of Age

Case Report and Review of the Literature

Pascoe, Edward M. MBBS*; Free, Matthew MBBS*; Mackie, Peter S. PhD, FRACS*; Donnan, Leo FRACS; O’Sullivan, Mark FRACS; Sullivan, Michael J. PhD, FRACP; Heath, John A. PhD, FRACP§

Journal of Pediatric Hematology/Oncology: October 09, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001315
Clinical and Laboratory Observations: PDF Only

Background: Osteosarcoma in children below the age of 5 is extremely rare.

Observation: We report on a previously well 14-month-old male infant, who presented with a reluctance to weight-bear on his right leg and had an associated limp. Plain imaging and a magnetic resonance imaging scan demonstrated a lytic lesion in the right distal femur. An open surgical biopsy confirmed the diagnosis of osteosarcoma. There was no significant family history of cancer and genetic screening for Li-Fraumeni syndrome was negative.

Conclusions: This case highlights the importance of timely consideration of osteosarcoma in an infant, when the clinical presentation and medical imaging are consistent with that diagnosis.

*Departments of Orthopaedic Surgery

§Paediatric Oncology, Royal Hobart Hospital, Tas, Hobart

Department of Orthopaedic Surgery

Children’s Cancer Centre, Royal Children’s Hospital, Melbourne, Vic., Australia

The authors declare no conflict of interest.

Reprints: John A. Heath, PhD, FRACP, Department of Paediatric Oncology, Royal Hobart Hospital, 48 Liverpool St, Hobart, Tas 7000, Australia (e-mail:

Received January 31, 2018

Accepted July 25, 2018

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