Major Issues of Care in Thalassemia Major Children RefugeesHamouni, Eglantine BM*; Armari, Corinne MD†; Dupuis, Clémentine MD*; Giroux-Lathuile, Claudine MD‡; Petit, Audrey BM*; Plantaz, Dominique MD, PhD†,§,∥; Adjaoud, Dalila MD†; Rubio, Amandine MD, PhD*,§,∥Journal of Pediatric Hematology/Oncology: August 31, 2018 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/MPH.0000000000001288 Clinical and Laboratory Observations: PDF Only Buy PAP Abstract Author InformationAuthors Article MetricsMetrics Beta thalassemia major (βTM) is the most common inherited hemoglobinopathy. Management essentially focuses on preventing and treating complications. Conventional treatment is based on a regular blood transfusion program, and chelation therapy. Management essentially focuses on preventing and treating complications. Severe complications of βTM are very rarely seen in children in Europe. In the context of the migrant crisis, pediatricians will be confronted with the challenge of managing severe complicated βTM. We report the case of 2 Syrian 10-year-old twin girls who arrived to France with numerous and severe complications of βTM: hemochromatosis, alloimmunization, hypopituitarism, osteopenia… Their clinical management, which led to successful vital and functional improvement, is reported in this article. Departments of *Pediatrics †Pediatric Immunogy-Oncology ‡French Blood Establishment, University Hospital of Grenoble §University of Grenoble Alpes ∥INSERM CIC1406, Grenoble, France The authors declare no conflict of interest. Reprints: Corinne Armari, MD, Department of Pediatric Immunogy-Oncology, University Hospital of Grenoble, F-38000 Grenoble, France (e-mail: firstname.lastname@example.org). Received March 17, 2018 Accepted July 15, 2018 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.