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Late Recurrence of Wilms Tumor After 17 Years

A Case Report

Park, Woo Young MD*; Hong, Kyung Taek MD*,†; Ahn, Hong Yul MD*,†; Choi, Jung Yoon MD*,†; Kang, Hyoung Jin MD, PhD*,†; Park, Sung Hye MD, PhD; Shin, Hee Young MD, PhD*,†

Journal of Pediatric Hematology/Oncology: April 03, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001473
Clinical and Laboratory Observations: PDF Only

Wilms tumor is the most common renal malignancy in children. Most of Wilms tumor recurrences occur within 2 years of the first diagnosis. Relapse after 5 years after the first diagnosis is called “late recurrence” and is rare in Wilms tumor. There are few case reports or small series of late recurrence of Wilms tumor. Because of the rarity of late recurrence of Wilms tumor, there is no clear guideline for its management. We describe a case of late recurrence of Wilms tumor as a remote metastasis in the lung at 18 years after the first diagnosis and 17 years after the second remission, which was achieved by radiotherapy and high-dose chemotherapy with autologous stem cell rescue. After late recurrence, the patient was treated by surgery and adjuvant chemotherapy, and remained disease-free for 11 months. Several very late recurrences of Wilms tumor in the literature are reviewed.

Departments of *Pediatrics

Pathology, Seoul National University College of Medicine

Seoul National University Cancer Research Institute, Seoul, Republic of Korea

Supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1720390).

The authors declare no conflict of interest.

Reprints: Kyung Taek Hong, MD, Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Republic of Korea (e-mail:

Received December 16, 2018

Accepted February 20, 2019

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