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Langerhans Cell Histiocytosis With Vertebral Involvement Diagnosed and Treated Over the Last 15 Years in a Single Canadian Pediatric Academic Institution

Gatineau-Sailliant, Sophie MD*; Grimard, Pascale*; Miron, Marie-Claude MD; Grimard, Guy MD; Carret, Anne-Sophie MD*; Leclerc, Jean-Marie MD*

Journal of Pediatric Hematology/Oncology: March 06, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001439
Clinical and Laboratory Observations: PDF Only

We report 11 children with vertebral lesion of Langerhans cell histiocytosis (LCH) diagnosed and treated between 2000 and 2015. Vertebral lesions were usually present at LCH diagnosis. No child developed neurological symptoms. Among 29 vertebral lesions, only 2 were unstable. Chemotherapy was used in all children but 3. A LCH recurrence was observed in 6 patients, involving vertebrae in 4 cases. All children were disease-free at their last follow-up. Sequelae were more often radiologic than clinical. Since potential recurrences and incomplete bone regeneration exist, discussion about optimal treatment and long-term follow-up of vertebral lesions are essential.

*Hematology-Oncology Division

Departments of Radiology

Orthopedics, Sainte-Justine University Health Center, University of Montreal, Montreal, QC, Canada

The authors declare no conflict of interest.

Reprints: Sophie Gatineau-Sailliant, MD, Hematology-Oncology Division, Sainte-Justine University Health Center, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada H3T 1C4 (e-mail:

Received July 11, 2018

Accepted January 11, 2019

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