We report 11 children with vertebral lesion of Langerhans cell histiocytosis (LCH) diagnosed and treated between 2000 and 2015. Vertebral lesions were usually present at LCH diagnosis. No child developed neurological symptoms. Among 29 vertebral lesions, only 2 were unstable. Chemotherapy was used in all children but 3. A LCH recurrence was observed in 6 patients, involving vertebrae in 4 cases. All children were disease-free at their last follow-up. Sequelae were more often radiologic than clinical. Since potential recurrences and incomplete bone regeneration exist, discussion about optimal treatment and long-term follow-up of vertebral lesions are essential.
Departments of †Radiology
‡Orthopedics, Sainte-Justine University Health Center, University of Montreal, Montreal, QC, Canada
The authors declare no conflict of interest.
Reprints: Sophie Gatineau-Sailliant, MD, Hematology-Oncology Division, Sainte-Justine University Health Center, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada H3T 1C4 (e-mail: firstname.lastname@example.org).
Received July 11, 2018
Accepted January 11, 2019