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Infusion of Hematopoietic Stem Cell Products Using Pump Mechanism

An Approach Worth Consideration?

Kissoon, Trisha MD*; Godder, Kamar MD*; Fort, John MD

Journal of Pediatric Hematology/Oncology: April 24, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001491
Clinical and Laboratory Observations: PDF Only

Hematopoietic stem cell transplantation using progenitor cells is a potentially curative treatment option for patients with high-risk malignancies and nonmalignant hematologic, immunologic, and genetic conditions. There is a need for evidence regarding safe practices and controlled infusion processes. Syringe and intravenous infusion pumps are not commonly used to deliver hematopoietic stem cell products (HPCs) due to a paradigm of thought that suggests that the pressure from the pump might damage the HPCs. Here, we describe a retrospective analysis of 114 patients who received HPC infusions using either a syringe or intravenous pump, providing support for this method along with successful engraftment data. This method may be a viable option to obtain reliable and consistent infusion rates, especially in pediatrics. To the best of our knowledge, this is the only study to date demonstrating safely using syringe and intravenous pump mechanisms in the setting of autologous and allogeneic pediatric stem cell transplantation.

*Nicklaus Children’s Hospital, Miami

University of Florida Shands Children’s Hospital, Gainesville, FL

Presented in abstract form at the Pediatric Bone Marrow Consortium Annual Meeting on May 02, 2018.

The authors declare no conflict of interest.

Reprints: Trisha Kissoon, MD, Department of Pediatrics, University of Florida Shands Children’s Hospital, 1600 SW Archer Road, HD 204, Gainesville, FL 32610 (e-mail:

Received July 11, 2018

Accepted March 21, 2019

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