Infantile Pyknocytosis An Uncommon Cause of Newborn Hemolytic AnemiaCastillo, Jayme BS*; Ness, Tara E. MD, MPH*,†; Mehta, Parth S. MD, MPH*,†Journal of Pediatric Hematology/Oncology: March 29, 2019 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/MPH.0000000000001461 Clinical and Laboratory Observations: PDF Only Buy PAP Abstract Author InformationAuthors Article MetricsMetrics Infantile pyknocytosis is a rare cause of neonatal hemolytic anemia, which presents in the first few weeks of life. We report a classic case of infantile pyknocytosis that presented to our institution with rebound hyperbilirubinemia after receiving phototherapy. The infant was found to have a hemoglobin of 5.8 g/dL, requiring a total of 15 mL/kg of red blood cells (in 2 separate transfusions) before discharge. The diagnosis was ultimately made by a review of the peripheral blood smear. We review the literature and suggest pediatricians consider infantile pyknocytosis on their differential when hemolytic anemia presents in the newborn period. *Baylor College of Medicine †Texas Children’s Hospital, Houston, TX The authors declare no conflict of interest. Reprints: Jayme Castillo, BS, Office of Student Affairs, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030 (e-mail: email@example.com). Received November 4, 2018 Accepted February 1, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.