Hand mirror cell (HMC) leukemia is a variant of acute lymphoblastic leukemia previously described in the adult population where lymphoblasts manifest distinctive hand mirror morphologic features. HMC has been previously identified in 23% of childhood acute lymphoblastic leukemia patients, but its prognostic significance in children is not well understood. Hypercalcemia is also uncommon in childhood leukemias. Hypercalcemia associated with HMC leukemia has not been previously reported. We report a 5-year-old boy with HMC B-lymphoblastic leukemia who presented with hypercalcemia.
*Division of Pediatric Hematology/Oncology
∥Division of Pediatric Endocrinology, McMaster Children’s Hospital
†Department of Pediatrics, McMaster University
‡Department of Medicine, Hamilton Health Sciences and McMaster University
§Department of Pathology, McMaster Children’s Hospital and McMaster University, Hamilton, ON
The authors declare no conflict of interest.
Reprints: Chantel Cacciotti, MD, Department of Pediatrics, Division of Pediatric Hematology/Oncology, McMaster Children’s Hospital, 1280 Main Street West, HSC room 3N27, Hamilton, ON, Canada L8S 4K1 (e-mail: firstname.lastname@example.org).
Received July 14, 2018
Accepted October 11, 2018