Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal syndrome of abnormal T-cell activation and cytokine production, which can be familial or secondary in nature. Although HLH can occur concomitantly with lymphomas, the development of HLH alongside Hodgkin lymphoma in children is unusual. Here we report the diagnostic evaluation and clinical course of 2 pediatric cases of HLH secondary to lymphocyte-depleted classic Hodgkin lymphoma. These cases highlight the need to be vigilant for this rare presentation and the difficulties in managing these patients.
Birmingham Children’s Hospital, Steelhouse Lane, Birmingham, UK
Birmingham Children’s Hospital Research Fund.
The authors declare no conflict of interest.
Reprints: Francis Mussai, MD, DPhil, Birmingham Children’s Hospital, Steelhouse Lane, Birmingham, B4 6NH, UK (e-mail: firstname.lastname@example.org).
Received January 27, 2018
Accepted November 30, 2018