Gray zone lymphoma is an aggressive disease for which appropriate management is still debated. We report a 15-year-old girl with a cervical mass, an enlarged ipsilateral tonsil, and anemia. Both sites showed hypermetabolism on F18-FG positron emission tomography/CT. Surgical resection was diagnostic of Epstein-Barr virus–negative gray zone lymphoma cervical and tonsillar involvement. No abnormality was found in cytogenetic analysis on tumor cells. However, exome sequencing in peripheral blood DNA revealed a germline mutation in TP53. Complete response was achieved after surgery and 6 cycles of rituximab with dose-adjusted etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin regimen.
Departments of *Haematology-Oncology
¶Charles Bruneau Cancer Center, University Hospital Center Ste-Justine, Research Center Montreal University
∥Department of Anatomical Pathology, Maisonneuve Hospital, Montréal, QC, Canada
The authors declare no conflict of interest.
Reprints: Dorothée Bouron-Dal Soglio, MD, PhD, Department of Anatomical Pathology, University Hospital Center Ste-Justine, 3175 Chemin de la Côte-Sainte-Catherine, Montréal, QC, Canada, H3T 1C4 (e-mail: email@example.com).
Received March 7, 2018
Accepted June 1, 2018