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Gastric Carcinoma as Second Malignant Neoplasm in a Survivor From High-risk Neuroblastoma

Hirano, Naoki MD*; Nishikawa, Kazuo MD; Hiratsuka, Takahiro MD, PhD; Suenobu, Souichi MD, PhD*,§; Ihara, Kenji MD, PhD*

Journal of Pediatric Hematology/Oncology: January 25, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001409
Clinical and Laboratory Observations: PDF Only

Childhood cancer survivors (CCSs) from high-grade malignancies, such as high-risk neuroblastoma, have been increased, and second malignant neoplasm, becomes a serious problem for CCSs. However, detailed reports about rare types of second cancer such as gastric cancer remain limited. We herein reported a female patient who developed diffuse type gastric carcinoma after 21 years from completion of treatment to high-risk neuroblastoma. We reviewed the previous cohort studies for second gastrointestinal cancer in CCSs and the case reports with second gastric carcinoma for CCSs. We presumed second gastric cancer was refractory for CCSs as well as for adult cancer survivors.

Departments of *Pediatrics

Medical Oncology and Hematology

Gastroenterological and Pediatric Surgery

§Department of Pediatrics, Division of General Pediatrics and Emergency Medicine, Oita University Faculty of Medicine, Yufu, Oita, Japan

The authors declare no conflict of interest.

Reprints: Naoki Hirano, MD, Department of Pediatrics, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama, Yufu, Oita 879-5593, Japan (e-mail:

Received July 28, 2018

Accepted December 11, 2018

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