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Disease Self-Efficacy and Health-Related Quality of Life in Adolescents With Sickle Cell Disease

Goldstein-Leever, Alana PsyD*,†; Peugh, James L. PhD‡,§; Quinn, Charles T. MD, MS§,∥; Crosby, Lori E. PsyD‡,§

Journal of Pediatric Hematology/Oncology: November 28, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001363
Clinical and Laboratory Observations: PDF Only

Adolescents and young adults (AYA) with sickle cell disease (SCD) are at risk for poor health-related quality of life (HRQOL). Research suggests that vulnerability factors (eg, disease severity) and self-management resources (eg, disease self-efficacy) jointly impact health outcomes, including HRQOL; however, this has not been studied among AYA with SCD. This study examined the relationship between disease self-efficacy, HRQOL, and disease severity in AYA with SCD. HRQOL was positively correlated with disease self-efficacy and negatively correlated with disease severity. Disease self-efficacy and severity accounted for 35% of variance in HRQOL. Findings support the impact of disease self-efficacy on HRQOL.

*Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital

Department of Pediatrics, The Ohio State University, Columbus

Division of Behavioral Medicine

Division of Hematology, Cincinnati Children’s Hospital Medical Center

§Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

A.G.-L. (ORCID iD: 0000-0002-2322-5822); J.L.P. (ORCID iD: 0000-0002-1134-5667); C.T.Q. (ORCID iD: 0000-0002-2372-2175); L.E.C. (ORCID iD: 0000-0001-6656-7745).

Supported in part by the National Heart, Lung, and Blood Institute at the National Institutes of Health (Grant no.: K07HL108720).

The authors declare no conflict of interest.

Reprints: Alana Goldstein-Leever, PsyD, The Ohio State University, Nationwide Children’s Hospital, 700 Children’s Drive Columbus, OH 43205-2664 (e-mail:

Received May 5, 2018

Accepted October 30, 2018

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