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Development of Secondary Osteosarcoma After TBI and Allogeneic Bone Marrow Transplant

A Case Series of 3 Patients

Scheuermann, Amanda DO*; Phelan, Rachel MD, MPH*,†; Browning, Meghen MD*,†

Journal of Pediatric Hematology/Oncology: February 22, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001442
Clinical and Laboratory Observations: PDF Only

Osteosarcoma can rarely occur as a subsequent malignant neoplasm after cancer therapy. Children who underwent treatment for cancer and received an allogeneic hematopoietic cell transplant are at a higher risk to develop secondary malignancies. Radiation is also a known risk factor, but estimating the quantitative risk is difficult due to the rarity of the condition and long latency period between primary and secondary cancer. In this report, we present 3 patients diagnosed with leukemia as young children who received hematopoietic cell transplants with total body irradiation as part of the conditioning regimen, and later went on to develop secondary osteosarcoma.

*Department of Pediatrics

Section of Pediatric Hematology/Oncology/BMT, Medical College of Wisconsin, Milwaukee, WI

The authors declare no conflict of interest.

Reprints: Amanda Scheuermann, DO, 8701 Watertown Plank Road, Milwaukee, WI 53226 (e-mail:

Received May 27, 2018

Accepted January 14, 2019

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