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Burkitt Leukemia With Precursor B-Cell Immunophenotype and Dual Translocation of t(14;18) and t(8;14) in a Child

Case Report and Review of the Literature

Odaman Al, Işik MD*; Bayram, Cengiz MD*; Koç, Başak MD*; Ersoy, Gizem MD*; Pasli Uysalol, Ezgi MD*; Aki, Hilal MD; Özdemir, Gül Nihal MD*

Journal of Pediatric Hematology/Oncology: November 28, 2018 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001354
Clinical and Laboratory Observations: PDF Only
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Background: Burkitt leukemia (BL) with the precursor B-cell immunophenotype is a rarely reported condition. The prognosis of such patients is similar to that of classic BL. However, the combination of chromosomal translocations associated with bcl-2 and c-myc rearrangement has a poor prognosis.

Observations: An 11-year-old child presented with fever and weakness. Bone marrow aspiration showed morphologically L1 type blasts and flow cytometry analysis was compatible with precursor B-cell immunophenotype. Cytogenetic analysis revealed a combination of t(8;14) and t(14;l8).

Conclusions: The combination of t(8;14) and t(14;l8) can exhibit different immunophenotypical and morphologic features in leukemias.

*Department of Pediatric Hematology and Oncology, Kanuni Sultan Suleyman Education and Research Hospital

Department of Pathology, Cerrahpaşa Faculty of Medicine, Istanbul University, Istanbul, Turkey

The authors declare no conflict of interest.

Reprints: Işik Odaman Al, MD, Department of Pediatric Hematology and Oncology, İstanbul Kanuni Sultan Süleyman Education and Research Hospital, İstanbul 34303, Turkey (e-mail: dr.odamanal@gmail.com).

Received May 24, 2018

Accepted October 18, 2018

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