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Benign Phyllodes Tumor in Children

A Study of 8 Cases and Review of the Literature

Hafeez, Safina MD; Balarezo, Fabiola MD; Ricci, Andrew Jr MD

Journal of Pediatric Hematology/Oncology: May 15, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001501
Clinical and Laboratory Observations: PDF Only

Phyllodes tumor (PT) occurs predominantly in middle-aged women, and although its occurrence in young women, adolescents, and even children is documented, presentation in the pediatric population has been the least well studied because of its rarity. Incompletely defined in children with PT are recurrence rates and optimal surgical management. We retrospectively studied the pathology database of Hartford Hospital from 2010 to 2017 to find all cases of PT in patients aged 18 years or younger. A series of 8 children/adolescents with breast masses diagnosed as benign PT were identified. Patients were aged 14 to 16 years (mean 15.2 y) and tumor size ranged from 2.2 to 7.2 cm (mean 4.4 cm). Both breasts were equally affected. All patients were treated with excision, tantamount to simple enucleation in most cases, and positive or “tumor-abutting” margins were universal. Mean follow-up after surgery was 27.5 months, during which time a single recurrence (at 9 mo) became manifest, which was re-excised and again showed benign PT. There were no pathologic features (including marginal status) that could have predicted the sole recurrence. Despite positive margins, the local recurrence rate for pediatric benign PT appears acceptably low (1 in 8 cases) such that reflex re-excision is probably unnecessary.

Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT

The authors declare no conflict of interest.

Reprints: Safina Hafeez, MD, Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102-5037 (e-mail:

Received November 17, 2018

Accepted January 26, 2019

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