Malignant or nonmalignant lymphoproliferative disorders together with repeated ear, nose, and throat infections should strongly motivate immunologic investigations. Indeed, we report a 7-year-old patient with a history of persistent abdominal symptoms along with recurrent ear, nose, and throat infections, who presented with intra-abdominal masses highly suggestive of a diagnostic of lymphoma, and who was diagnosed with activated-PI3K-delta syndrome, a recently described primary immunodeficiency prone to lymphoproliferation.
Departments of *Pediatrics
§Division of Clinical Pathology, University Hospitals Geneva
‡Pediatric Gastroenterology, Private Hospital Les Grangettes, Geneva, Switzerland
E.R. and M.S. contributed equally.
The authors declare no conflict of interest.
Reprints: Frederic Baleydier, MD, PhD, Department of pediatrics, University Hospitals Geneva, rue Willy Donze, 1205 Geneve, Switzerland (e-mail: firstname.lastname@example.org).
Received March 18, 2018
Accepted August 31, 2018