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A Unique Case of a Pediatric Patient With Blastic Plasmacytoid Dendritic Cell Neoplasm, Guillain Barre Syndrome, and Hemophagocytic Lymphohistiocytosis

Penney, Chelsea BSc*; Johnston, Donna L. MD; Story, Eden MD

Journal of Pediatric Hematology/Oncology: March 29, 2019 - Volume Publish Ahead of Print - Issue - p
doi: 10.1097/MPH.0000000000001464
Clinical and Laboratory Observations: PDF Only

Blastic plasmacytoid dendritic cell neoplasm is a rare hematopoietic malignancy with a poor prognosis that is seen primarily in the elderly population. We describe a pediatric patient with blastic plasmacytoid dendritic cell neoplasm who subsequently developed Guillain Barre syndrome followed by hemophagocytic lymphohistiocytosis. All 3 conditions are uncommon, particularly in the pediatric population. It is unclear whether this patient developed these disease states independently, whether they were due to a viral trigger or if she has an underlying immune dysfunction that could have contributed to the development of these conditions. The patient is currently in remission and awaiting further immune work-up.

*Faculty of Medicine, University of Ottawa

Division of Pediatric Hematology/Oncology, Children’s Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada

The authors declare no conflict of interest.

Reprints: Chelsea Penney, BSc, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8L1 (e-mail:

Received December 13, 2018

Accepted February 28, 2019

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