Cutaneous T-cell lymphomas are very rare in children. Although mycosis fungoides is the most common of these rare cutaneous T-cell lymphomas in children, transformation to an aggressive malignancy remains extremely uncommon, and there are no clear guidelines for clinical management in the pediatric population. In addition, the increased usage of next-generation sequencing for pediatric patients with unusual malignancies may result in the discovery of pathogenic germline mutations, though the association between these mutations and the patient’s cancer is not always clear. We present here a unique pediatric case of transformed mycosis fungoides in a patient with BRCA2 mutation.
*Children’s National Medical Center, Washington, DC
†National Institutes of Health, National Cancer Institute, Bethesda
‡Department of Dermatology, Howard University College of Medicine, Washington, DC
The authors declare no conflict of interest.
Reprints: Andrea M. Gross, MD, 10 Clinical Center Drive, 1-5742, Bethesda, MD 20892 (e-mail: email@example.com).
Received October 20, 2018
Accepted February 21, 2019