Clinical and Laboratory Observations: PDF OnlyNonsurgical Management of Acute Appendicitis in Sickle Cell DiseaseSahib, Sarah MD; Hanna, Mark MD; Miller, Scott T. MDAuthor Information Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, NY The authors declare no conflict of interest. Reprints: Scott T. Miller, MD, Department of Pediatrics, SUNY Downstate Health Sciences University, 450 Clarkson Avenue, Box 49, Brooklyn, NY 11362 (e-mail: email@example.com). Received July 19, 2019 Accepted February 12, 2020 Journal of Pediatric Hematology/Oncology: March 03, 2020 - Volume Publish Ahead of Print - Issue - doi: 10.1097/MPH.0000000000001774 Buy PAP Metrics Abstract A 9-year-old child with sickle cell disease (sickle beta zero thalassemia) was diagnosed to have acute appendicitis during a hospitalization for pain, acute chest syndrome, and exacerbation of asthma. Because of his high surgical risk, his appendicitis was treated nonsurgically, successfully deferring his appendectomy. He remains well after 1 year. This approach should be considered at least in other sickle cell patients with appendicitis, and perhaps other high-risk populations, if not all children with appendicitis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.