Online Articles: Clinical and Laboratory ObservationsPulmonary Blastomycosis: A Rare Cause of Acute Chest Syndrome and Prolonged Fevers in a Pediatric Patient With Sickle Cell DiseaseHalyko, Michael MD*; Thompson, Karen MD†; Ruiz, Juan P. MD‡; Scott, J. Paul MD*Author Information *Department of Pediatrics, Section of Pediatric Hematology/Oncology/BMT ‡Department of Pediatrics, Section of Pulmonary and Sleep Medicine, Medical College of Wisconsin, Milwaukee, WI †Department of Graduate Medical Education, San Antonio Uniformed Services Health Education Consortium (SAUSHEC), San Antonio Military Medical Center, Fort Sam Houston, TX The authors declare no conflict of interest. Reprints: Michael Halyko, MD, Children’s Wisconsin Pediatric Hematology/Oncology/BMT, 8701 Watertown Plank Road MFRC3018, Milwaukee, WI 53226 (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: November 2021 - Volume 43 - Issue 8 - p e1235-e1237 doi: 10.1097/MPH.0000000000002235 Buy Metrics Abstract Blastomyces is a fungus found in the soil of regions of North America including the Mississippi and Ohio River Valleys. It can be inhaled into the lungs and cause pneumonia and disseminated disease. Although blastomycosis is not widely reported in the sickle cell literature, sickle cell patients may be at increased risk of complications from blastomycosis pneumonia due to their immune compromise and risk of developing acute chest syndrome. We describe the case of a 13-year-old female with homozygous sickle cell disease who presented with pneumonia and acute chest syndrome and was found to have pulmonary blastomycosis. Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.