Online Articles: Original ArticlesVitamin D Insufficiency is Not Associated With Pediatric and Adolescent Immune Thrombocytopenia: A Study in Conjunction With its Receptor Genetic PolymorphismsShaheen, Iman Abdelmohsen PhD*; Aboukhalil, Reham PhD*,†; Abulata, Nelly PhD*; Abdel-Raouf, Rasha PhD‡; Meligy, Bassant PhD‡; Abdel-Dayem, Omnia PhD*Author Information Departments of *Clinical Pathology ‡Pediatrics, Cairo University, Cairo, Egypt †Department of Basic Medical Science, Unizha College of Medicine, Qassim University, Qassim, Kingdom of Saudi Arabia This work was carried out in KasrAl-Ainy School of Medicine, Cairo University. The authors declare no conflict of interest. Reprints: Iman Abdelmohsen Shaheen, PhD, Department of Clinical and Chemical Pathology, Section of Hematopathology, Cairo University, Cairo 11562, Egypt (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: January 2021 - Volume 43 - Issue 1 - p e1-e6 doi: 10.1097/MPH.0000000000001801 Buy Metrics Abstract Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous immunologic disorder. Vitamin D has immune-modulatory effects. The pleiotropic effects of vitamin D are exerted via vitamin D receptor (VDR) and its genetic alterations could influence its functions. In our study, we measured the serum 25-hydroxyvitamin D levels in 98 Pediatric and Adolescent ITP patients, in addition to 100 apparently healthy controls. Genetic polymorphisms of the VDR gene FokI, BsmI, ApaI, and TaqI were tested using specific restriction enzymes for each polymorphism. Vitamin D deficiency in the studied Pediatric age was a dominant factor, but it was found not to be associated with Pediatric ITP. However, patients carrying the FokI CC genotype had statistically higher vitamin D levels compared with those carrying other genotypes (P=0.036). Patients who were carriers of the BsmI G allele had a nearly 2-fold higher risk of ITP (odds ratio: 2.203; 95% confidence interval: 1.467-3.309). Therefore, the BsmI polymorphism of VDR could be considered a molecular risk factor for ITP. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.