Online Articles: Clinical and Laboratory ObservationsReversible Cerebral Vasoconstriction Syndrome and Sickle Cell Disease: A Case ReportRegling, Katherine DO*; Pomerantz, Daniel MD†; Narayanan, Sandra MD‡; Altinok, Deniz MD§; Sivaswamy, Lalitha MD∥; Marupudi, Neena I. MD, MS¶; Callaghan, Michael U. MD*; Martin, Alissa MD*Author Information *Carman and Ann Adams Department of Pediatrics, Division of Hematology/Oncology §Carman and Ann Adams Department of Pediatrics, Division of Radiology ∥Carman and Ann Adams Department of Pediatrics, Division of Neurology ¶Department of Pediatric Neurosurgery, Children’s Hospital of Michigan/Wayne State University †Carman and Ann Adams Department of Pediatrics, Wayne State University/Detroit Medical Center/Children’s Hospital of Michigan ‡Department of Neurosurgery, Detroit Medical Center, Wayne State University, Detroit, MI The authors declare no conflict of interest. Reprints: Katherine Regling, DO, Carman and Ann Adams Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children’s Hospital of Michigan/Wayne State University, 3901 Beaubien Street, Detroit, MI 48201 (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: January 2021 - Volume 43 - Issue 1 - p e95-e98 doi: 10.1097/MPH.0000000000001683 Buy Metrics Abstract Reversible cerebral vasoconstriction syndrome (RCVS), is rare in the pediatric population and is characterized by severe headaches and other neurologic symptoms. We present a case of RCVS occurring concomitantly with posterior reversible encephalopathy syndrome in an 8-year-old African American child with sickle cell disease (HbSS). Imaging studies including computed tomography, magnetic resonance imaging and cerebral angiography of the brain showed acute hemorrhagic stroke and a beaded appearance of peripheral cerebral vessels. In this report, we focus on the typical features of RCVS and discuss the underlying risk factors that may increase the risk in patients with HbSS disease. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.