Online Articles: Clinical and Laboratory ObservationsLangerhans’ Cell Histiocytosis Masquerading as Caroli’s DiseaseNarayanasamy Rajavelu, Thiagarajan MD*; Abimannane, Anitha MD*; Chinnaiah Govindhareddy, Delhi Kumar MD*; Kayal, Smita MD, DM†; Kar, Rakhee MD, DM‡Author Information Departments of *Pediatrics †Medical Oncology ‡Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India The authors declare no conflict of interest. Reprints: Delhi Kumar Chinnaiah Govindhareddy, MD, Department of Pediatrics, JIPMER, Puducherry 605006, India (e-mail: email@example.com). Journal of Pediatric Hematology/Oncology: October 2020 - Volume 42 - Issue 7 - p e620-e622 doi: 10.1097/MPH.0000000000001495 Buy SDC Metrics Abstract Langerhans’ cell histiocytosis is an uncommon disease in children with varied clinical presentation. Multisystem form of this disorder usually affects organs like the bones, skin, liver, spleen, lungs, and the central nervous system. We describe here the clinical details of a 2-year-old girl with involvement of unusual sites like the parotid glands and the nails. This child also had multiple cystic lesions in the liver leading to a misdiagnosis of Caroli’s disease. Knowledge about the uncommon manifestations of this rare disorder helps in early diagnosis and treatment. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.