Clinical and Laboratory ObservationsA Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral RetinoblastomaFarouk Sait, Sameer MD*,†; Haque, Sofia MD‡,§; Karimi, Sasan MD‡,§; Rebeiz, Karim J. MD‡; Francis, Jasmine H. MD∥; Marr, Brian P. MD∥; Abramson, David H. MD∥,¶; Souweidane, Mark M. MD#,**; Dunkel, Ira J. MD*,†Author Information Departments of *Pediatrics ‡Radiology ∥Surgery #Neurosurgery, Memorial Sloan Kettering Cancer Center Departments of §Radiology †Pediatrics ¶Ophthalmology **Neurosurgery, Weill Cornell Medical College, New York, NY This research was funded in part through the NIH/NCI Cancer Center Support Grant P30 CA008748. The authors declare no conflict of interest. Reprints: Ira J. Dunkel, MD, Department of Pediatrics, Memorial Sloan Kettering Cancer Center, H 1107, 1275 York Avenue, New York, NY 10065 (e-mail: firstname.lastname@example.org). Journal of Pediatric Hematology/Oncology: April 2020 - Volume 42 - Issue 3 - p 238-243 doi: 10.1097/MPH.0000000000001523 Buy SDC Metrics Abstract We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.