Clinical and Laboratory ObservationsDisease Self-Efficacy and Health-Related Quality of Life in Adolescents With Sickle Cell DiseaseGoldstein-Leever, Alana PsyD*,†; Peugh, James L. PhD‡,§; Quinn, Charles T. MD, MS§,∥; Crosby, Lori E. PsyD‡,§Author Information *Division of Pediatric Psychology and Neuropsychology, Nationwide Children’s Hospital †Department of Pediatrics, The Ohio State University, Columbus ‡Division of Behavioral Medicine ∥Division of Hematology, Cincinnati Children’s Hospital Medical Center §Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH A.G.-L. (ORCID iD: 0000-0002-2322-5822); J.L.P. (ORCID iD: 0000-0002-1134-5667); C.T.Q. (ORCID iD: 0000-0002-2372-2175); L.E.C. (ORCID iD: 0000-0001-6656-7745). Supported in part by the National Heart, Lung, and Blood Institute at the National Institutes of Health (Grant no.: K07HL108720). The authors declare no conflict of interest. Reprints: Alana Goldstein-Leever, PsyD, The Ohio State University, Nationwide Children’s Hospital, 700 Children’s Drive Columbus, OH 43205-2664 (e-mail: firstname.lastname@example.org). Received May 5, 2018 Accepted October 30, 2018 Journal of Pediatric Hematology/Oncology: March 2020 - Volume 42 - Issue 2 - p 141-144 doi: 10.1097/MPH.0000000000001363 Buy Metrics Abstract Adolescents and young adults (AYA) with sickle cell disease (SCD) are at risk for poor health-related quality of life (HRQOL). Research suggests that vulnerability factors (eg, disease severity) and self-management resources (eg, disease self-efficacy) jointly impact health outcomes, including HRQOL; however, this has not been studied among AYA with SCD. This study examined the relationship between disease self-efficacy, HRQOL, and disease severity in AYA with SCD. HRQOL was positively correlated with disease self-efficacy and negatively correlated with disease severity. Disease self-efficacy and severity accounted for 35% of variance in HRQOL. Findings support the impact of disease self-efficacy on HRQOL. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.