Clinical and Laboratory ObservationsChemoradiotherapy for Unresectable INI1-negative Chordoma in a ChildMiyahara, Hiroyuki MD*; Nodomi, Seishiro MD*; Umeda, Katsutsugu MD†; Itasaka, Satoshi MD‡; Waki, Kenji MD*; Imai, Tsuyoshi MD*Author Information *Department of Pediatrics, Kurashiki Central Hospital ‡Department of Radiation Oncology, Kurashiki Central Hospital, Okayama †Department of Pediatrics, Kyoto University, Kyoto, Japan Parents provided informed consent for the publication of photographs under the guidelines of the Medicine Ethics Committee in Kurashiki Central Hospital. The authors declare no conflict of interest. Reprints: Seishiro Nodomi, MD, 1-1-1 Miwa, Kurashiki City, Okayama 710-8602, Japan (e-mail: email@example.com). Received May 1, 2018 Accepted September 4, 2018 Journal of Pediatric Hematology/Oncology: January 2020 - Volume 42 - Issue 1 - p 65–68 doi: 10.1097/MPH.0000000000001318 Buy Metrics Abstract The characteristics of chordomas in children are distinct from those in adults. In particular, the prognosis of patients with INI1-negative chordoma is dismal. The standard treatment for localized chordoma, complete surgical resection with a wide margin, is seldom feasible for chordomas arising at the clivus in children, mainly due to associated complications. Therefore, other treatments for unresectable chordomas in children, including chemoradiotherapy, must be explored. Here, we report a 7-year-old girl with an INI1-negative chordoma of the clivus, who responded to conventional chemotherapy plus radiotherapy. Without surgical resection, she remains alive after 1 year and 7 months of the initial diagnosis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.