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Importance of Acute Lymphoblastic Leukemia-type Therapy for Bilineal Acute Leukemia

Nakagawa, Shunsuke MD; Okamoto, Yasuhiro MD; Kodama, Yuichi MD, PhD; Nishikawa, Takuro MD, PhD; Tanabe, Takayuki MD; Kawano, Yoshifumi MD, PhD

Journal of Pediatric Hematology/Oncology: August 2019 - Volume 41 - Issue 6 - p 504–506
doi: 10.1097/MPH.0000000000001309
Clinical and Laboratory Observations
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We examined 3 pediatric patients with bilineal acute leukemia. Patient 1 with B-cell acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia (AML) with B-ALL dominance responded well to prednisolone and ALL-type induction therapy. Patients 2 and 3 with T-ALL and AML with AML dominance responded poorly to prednisolone. Patient 2 was resistant to AML-type therapy; patient 3 was resistant to ALL-type induction therapy until day 15. However, all 3 patients eventually achieved complete remission after ALL-type induction therapy. Thus, ALL-type induction therapy should be initiated for bilineal acute leukemia even with AML-dominant, poor prednisolone response, or poor early response features.

Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

The authors declare no conflict of interest.

Reprints: Yasuhiro Okamoto, MD, Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City 890-8520, Japan (e-mail: okamoto@m2.kufm.kagoshima-u.ac.jp).

Received March 10, 2018

Accepted August 8, 2018

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