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Trilineage Dysplasia in an Adolescent With Germline GATA2 Mutation

Gardner, Juli-Anne MD*,†; Devitt, Katherine A. MD*,†

Journal of Pediatric Hematology/Oncology: July 2019 - Volume 41 - Issue 5 - p 392–393
doi: 10.1097/MPH.0000000000001469
Morphology Corner
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The GATA family of DNA binding proteins consists of six different transcription factors (GATA1-6), each with diverse biologic function. The GATA2 protein has been shown to be vital for proliferation and maintenance of hematopoietic stem cells; mutations result in variable phenotypes including myelodysplastic syndrome.

*Department of Pathology and Laboratory Medicine, University of Vermont Medical Center

Larner College of Medicine at the University of Vermont, Burlington, VT

The authors declare no conflict of interest.

Reprints: Juli-Anne Gardner, MD, Department of Pathology and Laboratory Medicine, University of Vermont Medical Center, 111 Colchester Ave., Burlington, VT 05401 (e-mail: juli-anne.gardner@uvmhealth.org).

Received September 19, 2018

Accepted February 18, 2019

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