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MYCN Amplified Relapse Following Resolution of MYCN Nonamplified 4S Neuroblastoma With Placental Involvement

A Case Report and Review of the Literature

Langenberg-Ververgaert, Karin P.S. MD*; Renzi, Samuele MD; Chung, Catherine T. MD; Shago, Mary PhD; Lo, Winnie PhD§; Davidson, Scott PhD§; Villani, Anita MD; Baruchel, Sylvain MD; Irwin, Meredith S. MD; Morgenstern, Daniel A. MD, PhD

Journal of Pediatric Hematology/Oncology: July 2019 - Volume 41 - Issue 5 - p 388–391
doi: 10.1097/MPH.0000000000001515
Medical Progress
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Congenital neuroblastoma with placental involvement is exceptionally rare, but mortality is high. Detailed examination of placenta including MYCN amplification and segmental chromosomal aberrations should be performed in all suspected cases, as it is noninvasive and readily available. Maternal dissemination has not been reported. In this manuscript, we describe an infant with placental diagnosis of MYCN nonamplified congenital neuroblastoma. This is the first report of a recurrence of congenital 4S neuroblastoma following resolution in which MYCN amplification is only detected in the recurrence. Germline sequencing using a large comprehensive cancer panel did not reveal variants in candidate cancer predisposition genes.

*Department of Translational Research, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

Departments of Haematology/Oncology, Division of Paediatrics

Paediatric Laboratory Medicine

§Genetics and Genome Biology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

The authors declare no conflict of interest.

Reprints: Karin P.S. Langenberg-Ververgaert, MD, Department of Translational Research, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (e-mail: k.p.s.langenberg@prinsesmaximacentrum.nl).

Received January 8, 2019

Accepted April 16, 2019

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