Online Articles: Clinical and Laboratory ObservationsRecurrent Severe Iron Deficiency Anemia and Thrombocytopenia in an Adolescent MaleGiordano, Lisa MD*; Llanos-Chea, Alejandro MD†; Monde, Alexandra MD‡; Mulinge, Ivy MD§; Dighe, Dipti MD∥ Author Information *Department of Pediatrics, Rush University Children’s Hospital ∥John H. Stroger Jr. Hospital of Cook County, Chicago, IL †Massachusetts General Hospital for Children, Boston, MA ‡Holtz Children’s Hospital of University of Miami/Jackson Health System, Miami, FL §Valley Children’s Primary Care Group, Madera, CA The authors declare no conflict of interest. Reprints: Lisa Giordano, MD, Department of Pediatrics, Rush University Children’s Hospital, Professional Building, 1725 West Harrision St., Suite 710, Chicago, IL 60612 (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: March 2019 - Volume 41 - Issue 2 - p e116-e118 doi: 10.1097/MPH.0000000000001162 Buy Metrics Abstract An adolescent male presented with recurrent episodes over several years of severe iron deficiency anemia and associated severe thrombocytopenia. The anemia was secondary to chronic blood loss due to ulceration at the site of an ileocolonic anastomosis performed during infancy. We were able to demonstrate complete resolution of thrombocytopenia with the administration of iron, and without using steroids, intravenous immunoglobulin, or platelet transfusions. This is the first reported case of an individual with multiple episodes over several years of thrombocytopenia secondary to recurrent severe iron deficiency anemia, illustrating a predisposition to this complication in a unique patient. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.