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Macropolycyte in Pediatrics

Lee, Anselm Chi-wai, MBBS, FRCPCH

Journal of Pediatric Hematology/Oncology: March 2019 - Volume 41 - Issue 2 - p 137
doi: 10.1097/MPH.0000000000001344
Morphology Corner

Macropolycytes are tetraploid neutrophils produced during accelerated myelopoiesis. They have been reported in adults with pernicious anemia, sepsis, and after cytotoxic chemotherapy. Two pediatric cases are reported, one after granulocyte colony-stimulating factor treatment and the other following Kawasaki disease, respectively.

Children’s Haematology and Cancer Centre, Mount Elizabeth Hospital, Singapore, Singapore

The authors declare no conflict of interest.

Reprints: Anselm Chi-wai Lee, MBBS, FRCPCH, Children’s Haematology and Cancer Centre, Level 4, Mount Elizabeth Hospital, 3 Mount Elizabeth, Singapore 228510, Singapore (e-mail:

Received September 12, 2018

Accepted September 21, 2018

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