Original ArticlesImpact of Prophylaxis on Bone Mineral Metabolism in Children With HemophiliaCulha, Vildan MD; Akpinar Tekgündüz, Sibel MD; Yarali, Hüsniye N. MD; Tunç, Bahattin MD; Özbek, Namik Y. MDAuthor Information Department of Hematology, Ankara Child Health and Disease, Hematology-Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey The authors declare no conflict of interest. Reprints: Vildan Culha, MD, Department of Hematology, Ankara Child Health and Disease, Hematology-Oncology Training and Research Hospital, University of Health Sciences, Yavuzevler Sok. No 30/16, Buyukesat, Ankara 06700, Turkey (e-mail: [email protected]). Journal of Pediatric Hematology/Oncology: March 2019 - Volume 41 - Issue 2 - p 121-123 doi: 10.1097/MPH.0000000000001394 Buy Metrics Abstract In this study, we aimed to investigate changes in calcium (Ca) metabolism in hemophilia patients (PWH). We also aimed to investigate the importance of diagnosis and treatment of factors impairing calcium metabolism and the significance of early diagnosis and prophylaxis with respect to these subjects. For all patients, serum calcium, phosphorus, alkaline phosphatase, 25 hydroxy vitamin D (25-OHD), parathormone (PTH), and calcitonin levels were evaluated. Bone mineral density (BMD) was assessed by dual-energy x-ray absorptiometry. Low BMD scores and 25-OHD deficiency were observed in 29 (74.4%) and 34 (87.2%) patients, respectively. Prophylaxis of PWH did not differ significantly in terms of 25-OHD levels and BMD scores. Patients in the prophylaxis group had significantly higher PTH levels (P=0.042). A negative correlation was found between PTH measurements and Z-score (P=0.008). In summary, our findings, with a small number of PWH in our study group, suggest that biochemical markers of bone turnover may be used to detect bone loss. Follow-up through annual BMD measurements coupled with appropriate exercise programs could be recommended. Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.