Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

Hepatoblastoma in a Child With Early-onset Cirrhosis

Bennett, Julie, MD*; Kirby-Allen, Melanie, MD*; Ng, Vicky, MD; Waye, John S., PhD; Chung, Catherine T., MD§; Shaikh, Furqan, MD, MSc*

Journal of Pediatric Hematology/Oncology: January 2019 - Volume 41 - Issue 1 - p e30–e33
doi: 10.1097/MPH.0000000000001097
Online Articles: Clinical and Laboratory Observations

Hepatoblastoma is the most common hepatic malignancy of childhood with known genetic predispositions and perinatal risk factors, with rare case reports occurring in the setting of cirrhosis. This case describes a young patient with cirrhosis attributed to early-onset hereditary hemochromatosis who was diagnosed with hepatoblastoma with uncommon histologic findings, evidence of chemotherapy resistance who ultimately succumbed to her disease. It is important to consider diagnoses beyond hepatocellular carcinoma in this scenario and consider early biopsy. With atypical histology, the tumor may respond poorly to conventional treatment and aggressive surgery or intensive therapy should be contemplated.

Departments of *Hematology/Oncology

Gastroenterology, Hepatology and Nutrition

§Pathology, The Hospital for Sick Children, Toronto

Division of Clinical Pathology, McMaster University, Pathology and Molecular Medicine, Hamilton, ON, Canada

The authors declare no conflict of interest.

Reprints: Julie Bennett, MD, The Hospital for Sick Children, Black Wing, Room 9401, 555 University Avenue, Toronto, ON, Canada M5G 1X8 (e-mail: julie.bennett@sickkids.ca).

Received August 31, 2017

Accepted October 24, 2017

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.