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A Congenital Case of Ependymoblastoma

A Rare and Aggressive Brain Tumor

Grassham, Courtney D., NNP*; Rady, Sara, MD*; Foster, Kimberly, MD; SantaCruz, Karen S., MD§; Kuttesch, John F., MD; Maxwell, Jessie R., MD*

Journal of Pediatric Hematology/Oncology: January 2019 - Volume 41 - Issue 1 - p e34–e37
doi: 10.1097/MPH.0000000000001117
Online Articles: Clinical and Laboratory Observations

Congenital brain tumors are rare, representing <2% of all childhood brain tumors. Of these, ependymoblastoma is a profoundly aggressive embryonal brain tumor that is included in the diagnostic entity known as an embryonal tumor with multilayered rosettes. This report of a congenital ependymoblastoma diagnosed at birth aims to highlight how much remains unknown about embryonal tumor with multilayered rosettes and the devastating prognosis of this condition. Despite recent advancements made in identifying molecular targets for therapy, this tumor continues to have a high rate of recurrence with few successful treatment options, especially when diagnosed in the newborn period.

Departments of *Pediatrics

Neurosurgery

Pediatric Hematology and Oncology

§Pathology, University of New Mexico, Albuquerque, NM

C.D.G. and S.R. contributed equally to this manuscript.

The authors declare no conflict of interest.

Reprints: Jessie R. Maxwell, MD, Department of Pediatrics, MSC10 5590, 1 University of New Mexico, Albuquerque, NM 87131-0001 (e-mail: jrmaxwell@salud.unm.edu).

Received September 7, 2017

Accepted November 21, 2017

Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.