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Sudden Intracranial Hemorrhage in a Patient With Atypical Chronic Myeloid Leukemia in Chronic Phase

Kouzuki, Kagehiro, MD*; Umeda, Katsutsugu, MD*; Saida, Satoshi, MD*; Kato, Itaru, MD*; Hiramatsu, Hidefumi, MD*; Funaki, Takeshi, MD; Kanda, Kenji, MD; Muramatsu, Hideki, MD§; Yoshida, Kenichi, MD; Ogawa, Seishi, PhD; Adachi, Souichi, MD

Journal of Pediatric Hematology/Oncology: November 2018 - Volume 40 - Issue 8 - p e553–e556
doi: 10.1097/MPH.0000000000001061
Online Articles: Clinical and Laboratory Observations

A 16-year-old boy was incidentally found to have hyperleukocytosis during a school physical examination. He was diagnosed with atypical chronic myeloid leukemia in chronic phase. Although treatment with hydoxyurea was started, his white blood cell count increased and he eventually developed lethal intracranial hemorrhage. Although very rare, intracranial hemorrhage should be considered as a possible complication in patients with atypical chronic myeloid leukemia, even in chronic phase, if they have hyperleukocytosis and thrombocytopenia.

Departments of *Pediatrics


Human Health Sciences, Graduate School of Medicine, Kyoto University

Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University Graduate School, Kyoto

Department of Pediatrics, Hikone Municipal Hospital, Hikone

§Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan

The authors declare no conflict of interest.

Reprints: Katsutsugu Umeda, MD, Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan (e-mail:

Received July 11, 2017

Accepted September 9, 2017

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