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Parvovirus B19-associated Hemophagocytic Lymphohistiocytosis in a Patient With Glucose-6-phosphate Dehydrogenase Deficiency

Zečkanović, Aida*; Perovnik, Matej*; Jazbec, Janez, MD, PhD; Petrovec, Miroslav, MD, PhD; Pokorn, Marko, MD, PhD§; Kavčič, Marko, MD, PhD

Journal of Pediatric Hematology/Oncology: November 2018 - Volume 40 - Issue 8 - p e550–e552
doi: 10.1097/MPH.0000000000001109
Online Articles: Clinical and Laboratory Observations

We report a case of a 12-year-old male with glucose-6-phosphate dehydrogenase deficiency presenting with clinical signs of sepsis and pancytopenia. Investigations revealed parvovirus B19 (PVB19)-associated hemophagocytic lymphohistiocytosis (HLH). The patient recovered fully and quickly with symptomatic treatment. Current evidence suggests that PVB19-associated HLH has a favorable prognosis. Mild undiagnosed cases of HLH may be the cause of pancytopenia in PVB19 infections.

*Faculty of Medicine, University of Ljubljana

Department for Pediatric Hematology and Oncology, University Children’s Hospital of Ljubljana

Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana

§Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia

The authors declare no conflict of interest.

Reprints: Marko Kavčič, MD, PhD, Department for Pediatric Hematology and Oncology, University Children's Hospital of Ljubljana, Bohoriceva 20, Ljubljana 1000, Slovenia (e-mail:

Received June 13, 2017

Accepted October 30, 2017

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