Online Articles: Original ArticlesP-glycoprotein Activity Correlates With Treatment Response in 2 Leukemia Child PatientsMuñoz-Pérez, María J. MD*; Casco, Stephania MD†; Garza-González, María d.C. MD‡; Soto-Vega, Elena MD, PhD*Author Information *Medicine School, Anáhuac University ‡Oncological research center UNE-UPAEP, Puebla †National Rehabilitation Institute, Mexico City, Mexico The authors declare no conflict of interest. Reprints: Elena Soto-Vega, MD, PhD, Medicine School, Anáhuac University, Puebla S.C., Calle Orión Norte S/N, La Vista Country Club, San Andrés Cholula, Puebla C.P 72810, Mexico (e-mail: firstname.lastname@example.org). Journal of Pediatric Hematology/Oncology: November 2018 - Volume 40 - Issue 8 - p e490-e494 doi: 10.1097/MPH.0000000000001278 Buy Metrics Abstract Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient´s death. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.