Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient´s death.
*Medicine School, Anáhuac University
‡Oncological research center UNE-UPAEP, Puebla
†National Rehabilitation Institute, Mexico City, Mexico
The authors declare no conflict of interest.
Reprints: Elena Soto-Vega, MD, PhD, Medicine School, Anáhuac University, Puebla S.C., Calle Orión Norte S/N, La Vista Country Club, San Andrés Cholula, Puebla C.P 72810, Mexico (e-mail: firstname.lastname@example.org).
Received February 8, 2018
Accepted July 6, 2018