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P-glycoprotein Activity Correlates With Treatment Response in 2 Leukemia Child Patients

Muñoz-Pérez, María J., MD*; Casco, Stephania, MD; Garza-González, María d.C., MD; Soto-Vega, Elena, MD, PhD*

Journal of Pediatric Hematology/Oncology: November 2018 - Volume 40 - Issue 8 - p e490–e494
doi: 10.1097/MPH.0000000000001278
Online Articles: Original Articles

Acute lymphoblastic leukemia is the most important childhood cancer. Multidrug resistance is an important factor of poor prognosis. We present the P-glycoprotein (P-gp) activity in 2 patients with different outcomes. Both patients had B-cell acute lymphoblastic leukemia; they were responding properly to the treatment, but one of them had an increment in the P-gp activity that correlates with an increment in the disease manifestation, the patient had to be hospitalized and developed sepsis and subsequently died. P-gp levels were correlated with disease progression. P-gp activity needs to be evaluated during treatment to assess and prevent disease relapse or the patient´s death.

*Medicine School, Anáhuac University

Oncological research center UNE-UPAEP, Puebla

National Rehabilitation Institute, Mexico City, Mexico

The authors declare no conflict of interest.

Reprints: Elena Soto-Vega, MD, PhD, Medicine School, Anáhuac University, Puebla S.C., Calle Orión Norte S/N, La Vista Country Club, San Andrés Cholula, Puebla C.P 72810, Mexico (e-mail: elenasoto_74@hotmail.com).

Received February 8, 2018

Accepted July 6, 2018

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