Secondary Logo

Institutional members access full text with Ovid®

Share this article on:

Pediatric Chronic Myeloid Leukemia Presenting With Extreme Thrombocytosis Simulating Essential Thrombocythemia

Boklan, Jessica L., MD*; Walsh, Alexandra M., MD*; de la Maza, Michelina C., MD*; Su, Leon L., MD; Nizzi, Francisco A. Jr, DO; Schafernak, Kristian T., MD

Journal of Pediatric Hematology/Oncology: August 2018 - Volume 40 - Issue 6 - p 456–457
doi: 10.1097/MPH.0000000000001154
Morphology Corner

A 10-year-old boy presented with spontaneous bruising and was found to have extreme thrombocytosis without neutrophilia/shift to immaturity, basophilia or eosinophilia. While the peripheral blood and bone marrow findings initially suggested essential thrombocythemia, BCR-ABL1 translocation was detected and chronic myeloid leukemia, chronic phase, was diagnosed. Apheresis for platelet depletion was performed as a bridge given the delayed effects of medical therapy.

*Division of Hematology/Oncology, Phoenix Children’s Hospital

Department of Pathology and Laboratory Medicine, Phoenix Children’s Hospital, Phoenix, AZ

The authors declare no conflict of interest.

Reprints: Kristian T. Schafernak, MD, 1919 E Thomas Road, Phoenix, AZ 85016 (e-mail:

Received November 9, 2017

Accepted December 17, 2017

Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.