Unexpected Effect of Propranolol and Prednisolone on Infantile Facial Rhabdomyosarcoma : Journal of Pediatric Hematology/Oncology

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Unexpected Effect of Propranolol and Prednisolone on Infantile Facial Rhabdomyosarcoma

Shilpakar, Rojina MD*; Lemperle, Gottfried MD†; Mentzel, Thomas PhD‡; Shakya, Jaswan MS*; Bhandari, Santosh Bikram MS*

Author Information

*Sushma Koirala Memorial Hospital, Sakhu-Kathmandu, Nepal

†Division of Plastic Surgery, San Diego School of Medicine, University of California, Frankfurt am Main

‡Institute for Dermatopathology, Friedrichshafen, Germany

The authors declare no conflict of interest.

Reprints: Gottfried Lemperle, Division of Plastic Surgery, San Diego School of Medicine, University of California, Wolfsgangstr. 64, D-60322 Frankfurt am Main, Germany (e-mail: [email protected]).

Journal of Pediatric Hematology/Oncology 39(8):p e460-e462, November 2017. | DOI: 10.1097/MPH.0000000000000925

Abstract

A 14-month-old Nepalese infant had developed a rapidly growing facial tumor originating from a dark spot on her upper eyelid. A cavernous hemangioma was suspected and treated with high doses of propranolol and prednisolone. Remission was dramatic. Histology confirmed alveolar rhabdomyosarcoma. Chemotherapy was planned but not carried out due to complicated logistics. The girl died at the age of 3. We present this case for discussion as to whether propranolol and prednisolone might be effective in rapidly growing rhabdomyosarcomas.

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.

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