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Immature Ovarian Teratoma: When to Give Adjuvant Therapy?

Faure-Conter, Cécile MD*; Pashankar, Farzana MD

Journal of Pediatric Hematology/Oncology: October 2017 - Volume 39 - Issue 7 - p 487–489
doi: 10.1097/MPH.0000000000000950
Invited Review

The question of giving or not adjuvant chemotherapy in pure ovarian immature teratomas (ITs) remains unsolved to date and illustrates differences in management between pediatric and adults oncologists. Because of the rarity of these tumors, this question has never been addressed through randomized trials. Standard of care for adult women with ovarian ITs is postoperative platinum based chemotherapy for all patients except FIGO stage IA, grade 1 tumors, whereas pediatric series concluded that surgery alone is curative for completely resected ovarian ITs, regardless of grade. Moreover the role of chemotherapy in incompletely resected tumors and its impact on the rate of malignant relapses needs to be better assessed. This emphasizes the urgent need for cooperation between adult and pediatric teams.

*Department of Pediatrics, Institut d’Hemato-Oncologie Pediatrique, Lyon, France

Yale University School of Medicine, New Haven, CT

The authors declare no conflict of interest.

Reprints: Cécile Faure-Conter, MD, Department of Pediatrics, Institut d’Hémato-Oncologie Pédiatrique, 1 Place Joseph Renault, 69008 Lyon, France (e-mail:

Received September 2, 2016

Accepted July 12, 2017

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.