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Posterior Reversible Encephalopathy Syndrome and Cerebral Sinus Thrombosis in a Case of Pediatric B-Cell ALL

Fraint, Ellen MD; Miller, Robin MD; Walter, Andrew MS, MD

Journal of Pediatric Hematology/Oncology: March 2017 - Volume 39 - Issue 2 - p e71–e73
doi: 10.1097/MPH.0000000000000728
Online Articles: Clinical and Laboratory Observations

Posterior reversible encephalopathy syndrome (PRES) and cerebral sinus thrombosis are 2 known complications of acute lymphoblastic leukemia and its treatment. We describe a patient with acute lymphoblastic leukemia whose course was complicated by both of these conditions. This case is novel both for the fact that PRES developed before the initiation of therapy and that PRES was followed shortly by the development of cerebral sinus thrombosis. Our patient’s story raises questions about our current understanding of the pathophysiology of PRES, and it suggests that PRES may actually be a predisposing risk factor for cerebral sinus thrombosis.

*Department of Pediatrics

Division of Hematology/Oncology, Nemours/A.I duPont Hospital for Children at Thomas Jefferson University, Wilmington, DE

The authors declare no conflict of interest.

Reprints: Ellen Fraint, MD, Department of Pediatrics, Nemours/A.I duPont Hospital for Children at Thomas Jefferson University, 1600 Rockland Rd, Wilmington, DE 19803 (e-mail:

Received July 7, 2015

Accepted November 29, 2016

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