Inflammatory myofibroblastic tumor (IMT), which expresses cyclooxygenase-2 (COX-2), can be effectively treated with COX-2 inhibitor. Here, we report a case of urinary bladder IMT in a 13-year-old boy. Although total cystectomy was initially planned for complete resection of the tumor, neoadjuvant treatment with COX-2 inhibitor and prednisolone reduced the size of the tumor and enabled complete resection of the tumor by partial cystectomy. Neoadjuvant treatment with COX-2 inhibitor and prednisolone for IMT of the bladder allowed a more conservative surgical procedure that preserved bladder function.
Departments of *Pediatrics
†Urology, Graduate School of Medical Science
‡Pathology, Kyoto Prefectural University of Medicine, Kyoto, Japan
Supported by a JSPS KAKENHI Grant-in-Aid Number (A) 25253095. This manuscript discusses off-label use of loxoprofen and meloxicam.
The authors declare no conflict of interest.
Reprints: Mitsuru Miyachi, MD, PhD, Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan (e-mail: email@example.com).
Received August 25, 2015
Accepted May 16, 2016